The following is a list of the top independent pharmaceutical, biotechnology and medical companies ranked by their revenue generated in (billion dollars) in the respective financial year, it does not include biotechnology companies that are now owned by, or part of, larger pharmaceutical groups.

The change is the companies relative position in this list, compared to their relative position in the prior year; i.e., an increase would be moving closer to rank 1 and vice versa. Green cells indicate years where revenue increased compared to the previous year, red cells indicate those years where there has been a decrease.